NEPHELOstar Plus

Microplate nephelometer for light-scattering and turbidity measurements

The world’s first and only laser-based microplate nephelometer was developed to meet high-throughput demands for fast compound solubility screens. The NEPHELOstar® Plus detects insoluble particles in liquid samples by measuring forward scattered light and can be used for turbidity measurements, drug solubility screening, protein binding kinetics, microbial growth, and petroleum process control.

Technical Specification

Detection modes
Nephelometry (light scattering)
Measurement modes
Endpoint and kinetic
Microplate formats
Up to 384-well plates
Wavelength selection


Wavelength 635±10 nm
Side window photodiode detector
Reagent injection

Up to 2 built-in reagent injectors

Injection at measurement position (6 to 384-well)

Individual injection volumes for each well (3 to 500 µL)

Variable injection speed up to 420 µL / s

Up to four injection events per well

Reagent back flushing
Read times

Depend on assay conditions and liquid surface stability

Shortest times possible: 16 s (96), 47 s (384)
Linear, orbital, and double-orbital with user-definable time and speed

+4°C above ambient up to 45°C or 60°C

The upper heating plate of the incubation chamber operates at 0.5°C more than the lower plate. This prevents condensation build-up on the lid or sealer.